The Sex & Gender in Neurodegeneration Consortium.
A coordinated, large-scale effort to close one of the most consequential gaps in neurodegeneration research.
Our mission
To unify global data and expertise to integrate sex and gender into neurodegeneration research, creating a foundation for more precise, translational science.
Our leadership
S|GN is led by an international team of leading physician-scientists and researchers specializing in Alzheimer's disease, aging, and neurodegeneration.
Co-leads
Scientific advisory board
- Kaitlin Casaletto - Chair, University of California, San Francisco
- Robbie Brinton - University of Arizona
- Silvia Maoli - Karolinska Institutet
- Lisa Mosconi - Weill Cornell Medicine/New York-Presbyterian Hospital
- Ozama Ismail - Alzheimer's Association
- Chi Momoh - Wake Forest University
- Nina Silverberg - NIH
- Keenan Walker - NIA
Featured publication
Researchers have spent decades establishing sex and gender differences in ADRD as a field priority, moving from documenting these differences to interrogating their drivers. Review the latest to come from our leadership.
Closing the Gap: Integrating Sex and Gender into Alzheimer's Disease Research
Researchers have spent decades establishing sex and gender differences in ADRD as a field priority, now moving from documenting these differences to interrogating their drivers. Read where critical gaps persist and what coordinated action is required to close them.
The road ahead
Backed by the Alzheimer’s Disease Data Initiative, S|GN is actively building the infrastructure the field needs. Here’s what we’re set to accomplish in the next two years.
ORGANIZATION MILESTONES
- Science Advisory Board initiated in Q2 2026
- Website launched at AAIC in Q3 2026
DATA & PUBLICATIONS
- Nature Aging correspondence: Published in Q2 2026
- Landscape and systematic review in Q3 2026
- Analysis of existing data scheduled in Q3 2026
- Cohort members confirmed in Q3 2026
- Working groups confirmed and researcher enrollment in Q3 2026
ACCESS
- Exclusive access for consortium members begins Q4 2026
- Access open to the research community Q4 2027
How we work
Our approach
The Consortium is building an integrated research ecosystem, bringing together the data,
researchers, and frameworks needed to catalyze progress in the field.
The work is unfolding in three mutually reinforcing phrases: harmonizing existing data, generating targeted new data, and expanding cohort participation.